List of Lab Publications

Chronologically Sorted
  1. Boudreaux D, Chaney J, Maiti T and Das C.* (2012) Contribution of active-site glutamine to rate enhancement in ubiquitin carboxy terminal hydrolases. FEBS Journal. doi: 10.1111/j.1742-4658.2012.08507.x.
  2. Maiti TK, Permaul M, Boudreaux D, Mahanic C, Mauney S, Das C* (2011) Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme. FEBs Journal 278 4917-4926.
  3. Davies C, Paul L, Kim M, and Das C* (2011) Structural and Thermodynamic Comparison of the Catalytic Domain of AMSH and AMSH-LP: Nearly Identical Fold but Different Stability. Journal of Molecular Biology 413 416-42.
  4. Andersson FI, McMorran L, Werrell EF, Crone WJ, Das C, Hsu SD, Jackson SE (2011). The Effect of Parkinson’s Disease Associated Mutations on the Stability, Structure and Dynamics of the Deubiquitinating Enzyme UCH-L1. Journal of Molecular Biology 407 261-271.
  5. Boudreaux, D, Maiti, T, Davies, C, Das C* (2010) Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proceedings of the National Academy of Sciences USA 107 9117-9122.
  6. Das C, Hoang, QQ, Kreinbring CA, Luchansky SJ, Meray RK, Ray SS, Lansbury PT, Ringe D, Petsko, GA (2006) Structural basis of conformational plasticity of the Parkinson’s disease- associated ubiquitin hydrolase UCH-L1. Proceedings of the National Academy of Sciences USA 103 4675-4680.
  7. Kornilova AY, Bihel F, Das C, Wolfe MS (2005) The initial substrate-binding site of gamma-secretase is located on presenilin near the active site. Proceedings of the National Academy of Sciences USA 102 3230-3235.
  8. Bihel F, Das C, Bowman MJ, Wolfe MS (2004) Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. Journal of Medicinal Chemistry 47 3931-3933.
  9. Esler WP, Das C, Wolfe MS (2004) Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics. Bioorganic and Medicinal Chemistry Letters 14 1935-1938.
  10. Aravinda S, Harini VV, Shamala N, Das C, Balaram P (2004) Structure and assembly of designed beta-hairpin peptides in crystals as models for beta-sheet aggregation. Biochemistry 43 1832-1846.
  11. Das C, Berezovska O, Diehl TS, Genet C, Buldyrev I, Tsai JY, Hyman BT, Wolfe MS (2003) Designed helical peptides inhibit an intramembrane protease. Journal of the American Chemical Society 125 11794-11795.
  12. Aravinda S, Shamala N, Das C, Sriranjani A, Karle IL, Balaram P (2003) Aromatic-aromatic interactions in crystal structures of helical peptide scaffolds containing projecting phenylalanine residues. Journal of the American Chemical Society 125 5308-5315.
  13. Kornilova AY, Das C, Wolfe MS (2003) Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications. Journal of Biological Chemistry 278 16470-16473.
  14. Wolfe MS, Esler WP, Das C (2002) Continuing strategies for inhibiting Alzheimer's gamma-secretase. Journal of Molecular Neuroscience 19 83-87.
  15. Aravinda S, Shamala N, Das C, Balaram P (2002) Structural analysis of peptide helices containing centrally positioned lactic acid residues. Biopolymers 64 255-267.
  16. Esler WP, Das C, Campbell WA, Kimberly WT, Kornilova AY, Diehl, TS, Ye W, Ostaszewski BL, Xia W, Selkoe DJ, Wolfe MS (2002) Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. Nature Cell Biology 4 E110-111.
  17. Karle IL, Das C, Balaram P (2001) Effects of hydrogen-bond deletion on peptide helices: structural characterization of depsipeptides containing lactic acid. Biopolymers 59 276-289.
  18. Das C, Shankaramma SC, Balaram P (2001) Molecular carpentry: piecing together helices and hairpins in designed peptides. Chemistry- A European Journal 7 840-847.
  19. Das C, Naganagowda GA, Karle IL, Balaram P (2001) Designed beta-hairpin peptides with defined tight turn stereochemistry. Biopolymers 58 335-346.
  20. Das C, Nayak V, Raghothama S, Balaram P (2000) Synthetic protein design: construction of a four-stranded beta-sheet structure and evaluation of its integrity in methanol-water systems. The Journal of Peptide Research 56 307-317.
  21. Karle IL, Das C, Balaram P (2000) De novo protein design: crystallographic characterization of a synthetic peptide containing independent helical and hairpin domains. Proceedings of the National Academy of Sciences USA 97 3034-3037.
  22. Zhao C, Polavarapu PL, Das C, Balaram P (2000) Vibrational circular dichroism of β-hairpin peptides. Journal of the American Chemical Society 122 8228-8231.
  23. Aravinda S, Shamala N, Pramanik A, Das C, Balaram P (2000) An unusual C-H...O hydrogen bond mediated reversal of polypeptide chain direction in a synthetic peptide helix. Biochemical and Biophysical research Communications 273 933-936.
  24. Das C, Raghothama S, Balaram P (1999) A four stranded β-sheet structure in a designed, synthetic polypeptide. Chemical Communications 967-968.
  25. Das C, Raghothama S, Balaram P (1998) A designed three stranded β-sheet peptide as a multiple β-hairpin model. Journal of the American Chemical Society 120 5812-5813.

Book Chapters

Chronologically Sorted
  1. Das C, Balaram P (1999) De novo protein design: β-hairpins and β-sheets. Book Chapter Perspectives in Structure Biology 313-324 (Editors: Vijayan M, Yathindra N, Kolaskar AS).